pentobarbital will lower the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Monitor Carefully (one)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a robust inducer of cytochrome P-4503A4; keep an eye o